I like to think that my thumbs are pretty badass. I, like a lot of gamers, have devoted a good amount of time in my life developing thumb speed, dexterity, strength, and, hey, even HP and MP. So for me, the Wiimote, while exciting, is a bit intimidating.The new heavily motion-based control scheme of the Wiimote puts experienced gamers back on a level playing field, and the inevitable Wii Mario Party that we will someday see will put us in our places, as thumb prestige is no longer the primary factor to victory. The more long-term (and less petty) issue here, though, is: will gamers be able to achieve the same level of virtuosity that they can with the standard button-based controllers?
The more motion required of a player, the more difficult the task at hand becomes (as we've seen from now-common "Wii soreness"). It's really just simple physics: pushing a button with a finger is much quicker than a flick of the wrist. This feels a bit limiting to me. Video games are supposed to let you feel like you are accomplishing feats far above what you could naturally. The Wiimote will definitely allow for more fluid control in areas such as movement and aiming, but speed will be a serious issue.
While the Wiimote might make certain controls easier (possible FPS's, if the controls are mapped well enough), I think that the Wiimote will have to sit contently on its newly acquired throne as ruler of the casual gamers. While hardcore gamers are singing its praises, I think that we'll see game reviews of multi-platform games start to discuss the advantages and disadvantages of Wii controls.